determination of acid-neutralizing capacity for over-the-counter antacids as per USP

The composition in each case includes an active antacid substance such as aluminum hydroxide-magnesium carbonate co-dried gel, dihydroxyaluminum sodium carbonate, magnesium trisilicate, aluminum hydroxide, aluminum basic carbonates, magnesium hydroxide and the like. The beneficial response of conditions and diseases treated with antacid compositions is in direct proportion to the amount of antacid ingested and its duration of action with the stomach. The pH of the test samples and their neutralizing effect on artificial gastric acid was determined and compared with that of water, the active control sodium bicarbonate and a marketed antacid preparation ENO.

These medications promise prompt relief for stomach distress. Too much food, certain types of food, or high levels of stress may cause the stomach to respond with an outpouring of acid.

When mixed with water, whether a chemical “donates” a charged particle (called an ion) to the solution-in this case, a hydrogen ion-or “accepts” one from it determines whether it’s an acidic or basic solution. An indicator changes color when exposed to such a mixture, depending on whether the solution is acidic or basic.

In other conditions where it is helpful to neutralise stomach acid. For example, for occasional bouts of indigestion (dyspepsia). To reduce the symptoms of acid reflux which may cause heartburn or inflammation of the gullet (oesophagitis). These conditions are sometimes called gastro-oesophageal reflux disease (GORD).

how do antacids lower stomach acidity by titration method

As a result of buffer formation, the pH is maintained at 6 to 7 when all of the tablet is dissolved. The pH will remain at or near this range despite the addition of more acid, within limits.

Depending on the levels of hydrogen ions in the solution, the indicator pigment undergoes a chemical reaction that changes its chemical structure, making it reflect a different wavelength of light and thereby change color. To tell if something is an acid or a base, you can use a chemical called an indicator. An indicator changes color when it encounters an acid or base. There are many different types of indicators, some that are liquids and others that are concentrated on little strips of “litmus” paper. Indicators can be extracted from many different sources, including the pigment of many plants.

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They are traditional, cheap, handy, and relatively safe – although they are not without risks and side effects can occur. Heartburn is also a common symptom of GERD, or gastroesophageal reflux disease. GERD is a long-term condition. In GERD, heartburn or other symptoms are frequent and persistent.

In particular, in people who have occasional bouts of mild dyspepsia or heartburn. Another group of medicines called alginates are found in some brands of antacid medication. Alginates are added to help protect the lining of the gullet (oesophagus) from stomach acid. Alginates include sodium alginate and alginic acid.


This solution represents an “upset” stomach. Record the color of the solution in Data Table 1. Record an approximate pH by comparison with the universal indicator color comparison chart.

Bismuth subsalicylate (Pepto-Bismol) is particularly useful if your burps smell like sulfur. These agents are indicated for the prevention and relief of heartburn, acid indigestion and sour stomach. They are available in half of the dosage strength of the prescription products. Although over-the-counter H 2 -receptor blockers do not act as rapidly as antacids, they provide longer relief of symptoms. Because of their slower onset of action, H 2 -receptor blockers are primarily used to prevent GERD symptoms.

Or stop indigestion before it occurs by drinking the mixture 30 minutes before eating. While peppermint can ease indigestion, you shouldn’t drink or eat peppermint when indigestion is caused by acid reflux.

how do antacids lower stomach acidity by titration method

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